CAR T cells induce a complete response in refractory Burkitt Lymphoma
نویسندگان
چکیده
منابع مشابه
CAR T-cell therapy in refractory large B-cell lymphoma.
Diffuse large B-cell lymphoma (DBLC) is the most common form of non-Hodgkin lymphomas. Patients with DBLC who have a relapse with chemotherapy-sensitive disease may be treated with high-dose chemotherapy followed by autologous stem-cell transplantation. However, the prognosis of patients whose diseases chemotherapy resistant, refractor to primary or salvage chemo-immunotherapy, or who have had ...
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Dendritic cells (DCs) induce pathogen-specific T cell responses. We comprehensively studied the effects of addition of maturation stimulus, fibroblasts (fibroblast conditioned medium), PHA activated T cells (T cell conditioned medium), and mixture of fibroblast & PHA activated T cells (FCM-TCCM) conditioned media on maturation of DCs. Monocytes were cultured with GM-CSF and IL-4 for five days. ...
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Introduction: Burkitt lymphoma is an aggressive subtype of Hodgkin lymphoma with a doubling time of 25 hours. It is characterized by a MYC gene coding alteration which results from a translocation of chromosome 8 on the MYC gene locus and immunoglobulin heavy-chain locus (IGH) on chromosome 14. Even though HIV infection is associated to an increased risk of Burkitt lymphoma, th...
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Introduction: Primary gastric lymphoma (PGL) is a rare tumor, whose differential diagnosis may become complicated without precise immunohistochemistry (IHC) and genetic analysis. Case Presentation: A 33-year-old woman presented with gastric cancer and had undergone gastrectomy without precise IHC and staging in another center. Inappropriate IHC after surgery showed diffuse large B-cell lymphom...
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Burkitt Lymphoma (BL) is a high grade Non-Hodgkins Lymphoma (NHL) that is characterized histopathologically by a mass of diffuse small non-cleaved B cell lymphocytes [1,2]. It is a highly aggressive lymphoma that frequently presents in extranodal sites with a very high proliferation rate. It is the fastest growing tumour, characterized by explosive growth with a doubling time of 24 hours. BL is...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2018
ISSN: 0268-3369,1476-5365
DOI: 10.1038/s41409-018-0235-0